Transplantation of Human Glial Restricted Progenitors and Derived Astrocytes into a Contusion Model of Spinal Cord Injury
نویسندگان
چکیده
منابع مشابه
Astrocytes derived from glial-restricted precursors promote spinal cord repair
BACKGROUND Transplantation of embryonic stem or neural progenitor cells is an attractive strategy for repair of the injured central nervous system. Transplantation of these cells alone to acute spinal cord injuries has not, however, resulted in robust axon regeneration beyond the sites of injury. This may be due to progenitors differentiating to cell types that support axon growth poorly and/or...
متن کاملComparison of human adipose-derived stem cells and chondroitinase ABC transplantation on locomotor recovery in the contusion model of spinal cord injury in rats
Objective(s):Spinal cord injury (SCI) is one of the most serious clinical diseases and its treatment has been a subject of interest to researchers. There are two important therapeutic strategies in the treatment of SCI: replacing lost tissue cells through cells implantation and scar elimination. Therefore, in this study we used human adipose-derived stem cells (hADSCs) implantation and injectio...
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The transplantation of neural stem/progenitor cells is a promising therapeutic strategy for spinal cord injury (SCI). In this study, we tested whether combination of neurotrophic factors and transplantation of glial-restricted precursor (GRPs)-derived astrocytes (GDAs) could decrease the injury and promote functional recovery after SCI. We developed a protocol to quickly produce a sufficiently ...
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Cellular abnormalities are not limited to motor neurons in amyotrophic lateral sclerosis (ALS). There are numerous observations of astrocyte dysfunction in both humans with ALS and in SOD1(G93A) rodents, a widely studied ALS model. The present study therapeutically targeted astrocyte replacement in this model via transplantation of human Glial-Restricted Progenitors (hGRPs), lineage-restricted ...
متن کاملtransplantation of adult monkey neural stem cells into a contusion spinal cord injury model in rhesus macaque monkeys
objective: currently, cellular transplantation for spinal cord injuries (sci) is the subject of numerous preclinical studies. among the many cell types in the adult brain, there is a unique subpopulation of neural stem cells (nsc) that can self-renew and differentiate into neurons. the study aims, therefore, to explore the efficacy of adult monkey nsc (mnsc) in a primate sci model. materials an...
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ژورنال
عنوان ژورنال: Journal of Neurotrauma
سال: 2011
ISSN: 0897-7151,1557-9042
DOI: 10.1089/neu.2010.1626